(go and) take a running jump 

To go away and leave one alone because what is being done or said is very irritating. Often used as an imperative.

走開(kāi)，不打擾某人，因?yàn)樗龌蛩f(shuō)的事令人惱火。常用作祈使句

走開(kāi)，一邊兒歇著去

A: The experiment might work better if you actually knew what you were supposed to be mixing together.

如果你真的知道要混合的是什么，這個(gè)實(shí)驗(yàn)可以做得更好。

B: You know what, Jenny? Why don't you take a running jump?

這樣吧，珍妮，你不如去一邊歇會(huì)？