Tough break:

倒霉

例句：

Tough break, James /d?eimz/. I know that must be hard for you. I'm sorry. 

詹姆斯，你真不走運(yùn)，我知道這對(duì)你來(lái)說(shuō)一定很難。對(duì)不起。

Just my luck:

倒霉

例句：

Just my luck to arrive after they had left. 

我總是這樣倒霉，他們離開(kāi)后我才趕到。

Go through a bad patch:

經(jīng)歷困難時(shí)期

例句： 

I'm sorry. I went through a bad patch there, when I was trying to find the right balance with my Meds.

很抱歉，那是我的人生低谷，吃藥吃的有點(diǎn)多。